Hormonal Research
HPG Axis, Reproductive Biology & Melanocortin Research
From HPG axis regulation to melanocortin receptor pharmacology — this category covers the reproductive, sexual function, and pigmentation research compounds in the Helixera library.
At a Glance
Hormonal research at Helixera spans three distinct mechanistic areas: HPG axis modulation (enclomiphene, kisspeptin, HCG), melanocortin receptor pharmacology (PT-141, Melanotan I, Melanotan II), and neuropeptide social/bonding biology (oxytocin). Understanding which level of the hormonal cascade a compound targets is key to selecting the right research tool.
The trans-isomer of clomiphene — blocks pituitary estrogen feedback to stimulate endogenous LH and testosterone production while preserving the entire HPG axis and spermatogenesis. Phase 3 data available.
Phase 3 Clinical · Read overview →The neuropeptide gatekeeper of the HPG axis — without kisspeptin signaling, GnRH neurons don't fire. Phase 2 IVF trigger data showing potential OHSS-reduction vs hCG.
Phase 2 Clinical · Read overview →LH analogue with 24-hour half-life. FDA approved for multiple indications. Used in TRT adjunct protocols to maintain testicular function and spermatogenesis; IVF ovulation trigger.
FDA Approved · Read overview →Central melanocortin agonist (MC3R/MC4R) acting on hypothalamic arousal circuits. FDA approved as Vyleesi for HSDD. Addresses the desire/motivation dimension of sexual function — not vascular mechanics.
FDA Approved · Read overview →Selective MC1R agonist. Drives eumelanin production without CNS arousal or appetite effects. FDA approved as Scenesse for erythropoietic protoporphyria.
FDA Approved · Read overview →Parent compound that led to both PT-141 and Melanotan I. Activates MC1R, MC3R, MC4R, MC5R — tanning plus sexual arousal plus appetite effects. The non-selective baseline for melanocortin research.
Substantial Preclinical · Read overview →The bonding neuropeptide. FDA approved for obstetric use; active research in autism (ASD), PTSD, social anxiety, and pair bonding neuroscience. Intranasal delivery enables CNS research.
FDA Approved + Active Research · Read overview →All compounds listed are for laboratory research use only. Not for human or veterinary use. Information based on publicly available scientific literature as of 2026. · Helixera Labs LLC © 2026