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Cognitive & Longevity Research

Cognitive & Longevity Research
Nootropics, Senescence Biology & Mitochondrial Aging

From Russian neuropeptides with decades of clinical use to frontier senolytic compounds targeting cellular aging at its source — this category covers the full spectrum of cognitive enhancement and longevity biology research.

Neuroprotection Mitochondrial Biology Senescence Telomere Biology Longevity

At a Glance

Compounds
9
Russian clinical
2 compounds
Aging hallmarks
5 addressed
Phase 2 data
SS-31, VIP
Mitochondrial
NAD+, SS-31, MOTS-c
Contents
Neuroprotective Mitochondrial Senescence
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About this category

Cognitive and longevity research at Helixera spans four mechanistic areas: neuroprotective peptides (Semax, Selank), mitochondrial biology (NAD+, SS-31, MOTS-c), telomere and aging biology (Epitalon, FOXO4-DRI), and neuromodulatory/circadian compounds (DSIP, VIP). Many of these target fundamental hallmarks of biological aging — not just symptoms.

Neuroprotective Peptides
Semax
ACTH-Derived Neuroprotective Peptide
BDNF-upregulating heptapeptide with decades of clinical use in Russia for stroke recovery and cognitive enhancement. Clean stimulating nootropic via ACTH analogue mechanism without steroid effects.
BDNFNeuroprotectiveCognitiveRussian Clinical
Russian Clinical DataRead overview →
Selank
Anxiolytic Nootropic Peptide
Tuftsin-derived anxiolytic with GABA modulation, no sedation, and no dependence liability. Dual CNS + immune modulation. Calming complement to Semax's stimulating profile.
AnxiolyticGABAImmuneRussian Clinical
Russian Clinical DataRead overview →
DSIP
Delta Sleep-Inducing Peptide
Original research sleep neuropeptide — 50 years of study. Promotes slow-wave delta sleep without sedation. Also modulates HPA axis cortisol and has shown efficacy in withdrawal symptom reduction.
Delta SleepHPA AxisNon-SedativeStress
Preclinical + Limited ClinicalRead overview →
VIP
Vasoactive Intestinal Peptide
Master circadian synchronizer, potent anti-inflammatory, and gut-brain axis regulator. Phase 2 data in rheumatoid arthritis and ARDS. One of the most multifunctional neuropeptides in biology.
CircadianAnti-InflammatoryGut-BrainPhase 2
Phase 2 ClinicalRead overview →
Mitochondrial Biology
NAD+
Nicotinamide Adenine Dinucleotide
Coenzyme essential for sirtuin activation, DNA repair, and cellular energy. Declines 40–60% with age. IV, oral, and precursor research models all available. Central to longevity biology.
SirtuinsDNA RepairEnergyLongevity
Extensive — Phase 1/2 ClinicalRead overview →
SS-31
Elamipretide — Mitochondrial Targeting
Tetrapeptide that directly stabilizes cardiolipin in the inner mitochondrial membrane. Phase 2 human data in heart failure and primary mitochondrial myopathy.
CardiolipinETCCardiacPhase 2
Phase 2 ClinicalRead overview →
MOTS-c
Mitochondria-Encoded Metabolic Regulator
Microprotein encoded in mitochondrial DNA. AMPK activation, exercise mimicry, insulin sensitivity. Declines with age — restoration is a longevity research target.
AMPKMitochondrialExercise MimeticAging
Active PreclinicalRead overview →
Telomere & Senescence Biology
Epitalon
Telomerase-Activating Tetrapeptide
Pineal-derived tetrapeptide showing telomerase activation in human somatic cells and 25–34% lifespan extension in rodent models. 30+ years of Russian clinical research.
TelomeraseLongevityPinealMelatonin
Russian Long-Term ClinicalRead overview →
FOXO4-DRI
Senolytic — Senescent Cell Clearing
D-amino acid peptide that disrupts FOXO4-p53 survival signaling in senescent cells — selectively triggering apoptosis in zombie cells while leaving healthy cells unaffected. 2017 Nature landmark paper.
Senolyticp53FOXO4Aging Hallmarks
Preclinical (Nature 2017)Read overview →

All compounds listed are for laboratory research use only. Not for human or veterinary use. This page is educational and based on publicly available scientific literature as of 2026. · Helixera Labs LLC © 2026